منابع مشابه
Everolimus induces Met inactivation by disrupting the FKBP12/Met complex
Inhibition of the mechanistic target of rapamycin (mTOR) is a promising treatment strategy for several cancer types. Rapamycin derivatives such as everolimus are allosteric mTOR inhibitors acting through interaction with the intracellular immunophilin FKBP12, a prolyl isomerase with different cellular functions. Although mTOR inhibitors have significantly improved survival of different cancer p...
متن کاملRese Met
ownloade kground: Estimates of human papillomavirus (HPV) concordance among sexual partners are imporr various public health activities, from counseling individual patients to predicting the effect of HPV ation. thods:We systematically searched the PubMed and EMBASE databases for studies of HPV concordance heterosexual couples published through 2008 in English. Two coders independently abstract...
متن کاملTargeting MET in Lung Cancer: Will Expectations Finally Be MET?
The hepatocyte growth factor receptor (MET) is a potential therapeutic target in a number of cancers, including NSCLC. In NSCLC, MET pathway activation is thought to occur through a diverse set of mechanisms that influence properties affecting cancer cell survival, growth, and invasiveness. Preclinical and clinical evidence suggests a role for MET activation as both a primary oncogenic driver i...
متن کاملImmunohistochemical studies on the gastrointestinal tract using antisera to Met-enkephalin and Met-enkephalin Arg6Phe7.
Antisera specific for the C-terminus of Met-enkephalin and two of its variants isolated from adrenal medulla and brain, namely Met-enk Arg6 and Met-enk Arg6Phe7, have been used in immunohistochemical studies of the gastrointestinal tract in rat, mouse and guinea pig. Met-enk and Met-enk Arg6Phe7-like immunoreactivities were found with similar distribution in nerve cell bodies of the myenteric p...
متن کاملHGF - MET and angiogenesis
1. Abstract 2. Significance of HGF-Met in molecular target therapy of cancer 3. NK4 as HGF-antagonist 4. Biological activity of NK4 as angiogenesis inhibitor 5. Experimental cancer treatment by gene expression of NK4 5.1. Inhibition of invasion-metastasis associated with Met inactivation by NK4 gene therapy 5.2. NK4 gene therapy using recombinant adenovirus for metastatic cancers 6. Conclusion ...
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ژورنال
عنوان ژورنال: Offset
سال: 1969
ISSN: 2204-3659,1445-9418
DOI: 10.15209/offset.v0i12.436